Prevalence and characteristics of pediatric hypertelorism: insights from Ugwolawo, Kogi State, Nigeria

Document Type : Original Article


Department of Anatomy, Faculty of Basic Medical Sciences, Adeleke University, P.M.B 250, Ede, Osun State, Nigeria


Background: Hypertelorism is a medical condition characterized by an abnormally increased distance between two organs or structures, particularly the eyes.
Objectives: The study aims to investigate the prevalence and characteristics of hypertelorism among 8–10-year-old children in Ugwolawo community of Kogi State, Nigeria.
Methods: Three hundred children (150 males and 150 females) were included in the study. Data on inner canthal distance (ICD), interpupillary distance (IPD), and outer canthal distance (OCD) were collected through physical examinations and questionnaires. Standardized photographs were taken to aid in further analysis and confirmation of hypertelorism. The data were analyzed using GraphPad Prism version 8, employing t-tests for comparisons involving variables such as gender, and Spearman's correlation coefficient to assess the association between age and the facial indices. The prevalence of hypertelorism in the study population was assessed, and potential risk factors were explored.
Results: The mean ages for male and female participants were 9.0±0.8 and 9.49 ± 0.5 years, respectively, while the overall mean age for all subjects was 9.25 ± 0.7 years. IPD, ICD, and OCD were assessed, and no statistically significant differences were found between males and females in terms of these indices. Additionally, Spearman's correlation coefficient indicated a significant correlation between age and OCD, but no significant correlations were observed for IPD and ICD. The medical history analysis showed that none of the participants had been diagnosed with hypertelorism, but 4% reported a family history of hypertelorism or craniofacial abnormalities.
Conclusion: The absence of diagnosed cases of hypertelorism in the studied population suggests a relatively low prevalence of the condition. However, the presence of family history in 4% of the participants highlights the potential role of genetic factors in hypertelorism. Larger-scale studies are recommended for deeper exploration of these findings.


Main Subjects

  1. Miamoto CB, Soares RL, de Carvalho ÉMG, Pereira LJ, Marques LS. Ocular hypertelorism in an orthodontic patient. Am J Orthod Dentofacial Orthop. 2011;139(4):544-550. doi:10.1016/j.ajodo.2009.09.023 PMid:21457866
  2. Pinto RO, Tonello C, Peixoto AP, de Jesus AS, Dos Santos-Pinto A, Raveli DB. Three-Dimensional Evaluation of Dental Arches in Individuals with Syndromic Craniosynostosis. Int J Dent. 2023; 2023:1043369. doi:10.1155/2023/1043369 PMid:36647423 PMCid:PMC9840551
  3. Soldanska M, Taub PJ. Orbital Hypertelorism: Surgical Management. Craniomaxillofacial Reconstructive and Corrective Bone Surgery. 2019:759-64. doi:10.1007/978-1-4939-1529-3_49
  4. Usman YM, Shugaba AL. The interpupillary distance and the inner and outer canthal distances. E3 J Sci Res. 2005; 3:00-3
  5. Pryor HB. Objective measurement of interpupillary distance. Pediatric. 1969; 44:973-7. doi:10.1542/peds.44.6.973
  6. Bhalla AK, Kaur H, Kaur R. Detection of ocular hypertelorism among Indian children. Indian J Med Res. 2022; 55(3-4): 364-372. doi:10.4103/ijmr.IJMR_758_20 PMid:36124511 PMCid:PMC9707680
  7. Carey JC. Hypertelorism. In Cassidy SB, Allanson JE (Eds.), Management of Genetic Syndromes (3rd ed.). Wiley-Blackwell.). 2007
  8. Bunty S. Hypertelorism. Statpearls. Gitanjli Sood (ed). Accessed on 22/06/2023.
  9. Cohen MM, Richieri-Costa A, Guion-Almeida ML, Saavedra D. Hypertelorism: interorbital growth, measurements, and pathogenetic considerations. Int J Oral Maxillofac Surg. 1995; doi:10.1016/S0901-5027(05)80465-5 PMid:8636632
  10. Sharma RK. Hypertelorism. Indian J Plastic Surg: official publication of the Association of Plastic Surgeons of India. 2014; PMID: 2559342
  11. Traboulsi EI. Strabismus. Genetic Diseases of the Eye (2nd ed.). Oxford University Press. 2011. doi:10.1093/med/9780195326147.001.0001
  12. Gupta VP, Sodhi PK, Pandey RM. Normal values for inner intercanthal, interpupillary, and outer intercanthal distances in the Indian population. Int J Clin Pract. 2003;57:25-9. doi:10.1111/j.1742-1241.2003.tb11392.x PMid:12587938
  13. Laestadius ND, Aase JM, Smith DW. Normal inner canthal and outer orbital dimensions. J Pediatr. 1969; 74(3):465-468. doi:10.1016/S0022-3476(69)80206-4 PMid:5764779
  14. Evereklioglu C, Doganay S, Er H, Gunduz A, Tercan M, Balat A, Cumurcu T. Craniofacial Anthropometry in a Turkish Population. Cleft Palate-Craniofac J. 2002; 39 (2): 208-28. doi:10.1597/1545-1569_2002_039_0208_caiatp_2.0.co_2 PMid:11879080
  15. Saheeb BD, Umweni AA, Obuekwe ON, Folaranmi N. Normal values of medial and lateral canthal distances in 3- to 8-year-old Nigerians. West Afr J Med. 2014; 23(2):56-6. doi:10.4314/wajm.v23i2.28110 PMid:15287297