Fullerene C60 nanoparticles potentiate the antioxidant defense system of the brain and liver by increasing catalase activity in normal rats

Document Type : Original Article

Authors

1 Department of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

10.22034/ncm.2023.360397.1056

Abstract

Background: Previous studies have shown that fullerene C60 nanoparticles and their derivatives possess antioxidant properties, both in vitro and in vivo.
Objectives: The aim of this study was to investigate the effects of orally administered C60 fullerene nanoparticles on the antioxidant capacity of the brain and liver of normal rats, especially on catalase activity.
Methods: Two groups of Wistar rats (n = 6) were studied for 8 weeks: a group that received no treatment and a group that received C60 fullerene nanoparticles orally at a dose of 1 mg/kg/day. Blood glucose and body weight were monitored throughout the study. At the end of the study, catalase activity in the brain and liver was assessed using the Aebi method.
Results: Blood glucose levels remained unchanged in treated rats compared to untreated rats. Results showed similar progressive weight gain in both groups. Fullerene C60 injection, on the other hand, significantly boosted catalase activity in treated rats' brains (0.340.10 U/mg protein) compared to untreated rats (0.120.03 U/mg protein) (p 0.05). Furthermore, fullerene C60 boosted mean catalase activity in treated rats' livers (6.140.76 U/mg protein) compared to untreated rats (2.071.43 U/mg protein) (p<0.05).
Conclusion: The findings suggest that fullerene C60 nanoparticles may enhance the antioxidant capacity of the brain and liver through the enhancement of catalase activity. This may have implications for the prevention of ROS accumulation and oxidative stress in various pathological situations.

Keywords

References

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Journal of Preventive and Complementary Medicine
Volume 2, Issue 1
February 2023
Pages 32-38

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History

  • Receive Date: 03 September 2022
  • Revise Date: 01 January 2023
  • Accept Date: 09 January 2023

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