Comparison of the effects of Persian shallot and garlic hydroalcoholic extracts on albumin glycation

Document Type : Original Article

Authors

1 Department of Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

2 Department of Clinical Biochemistry, Abadan School of Medical Sciences, Abadan, Iran

3 Department of Molecular Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Medical Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Abstract

Background: Hyperglycemia in diabetes leads to body protein glycation, altering its structure and function and causing later complications. Therefore, inhibition of the protein glycation reaction or breaking this linkage is crucial for reducing diabetes complications.
Objectives: This study aimed to compare the impact of hydroalcoholic extracts of Persian shallot and garlic on the level of in vitro albumin glycation.
Methods: This study aimed to examine the inhibitory effects of Persian shallot and garlic extracts at concentrations of 0.1, 0.2, and 1 g/dL on albumin glycation reactions. The assessment of glycation levels was conducted using thiobarbituric acid (TBA).
Results: Both Persian shallot and garlic extracts significantly inhibited the glycation reaction of albumin at all concentrations. Notably, the concentration of 1 g/dL exhibited the highest efficacy, displaying statistically significant variances (P < 0.05). The extent of linkage breaking is directly correlated with the concentration of the extracts and the duration of treatment. Furthermore, when administered at a concentration of 1 g/dL, the inhibitory effects of Persian shallot and garlic extracts were significantly different 48 hours after treatment, showing that Persian shallot had a greater impact.
Conclusion: The present study provides evidence that both Persian shallot and garlic possess the ability to inhibit albumin glycation and break the linkage between albumin and glucose.

Keywords

References

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Journal of Preventive and Complementary Medicine
Volume 1, Issue 4 - Serial Number 4
August 2022
Pages 197-203

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History

  • Receive Date: 17 July 2022
  • Revise Date: 09 August 2022
  • Accept Date: 11 August 2022

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