Antibacterial Activity of Modified Carvacrol against Staphylococcus epidermidis and Pseudomonas aeruginosa

Document Type : Original Article


1 Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

2 Department of Microbiology and Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Department of Medicinal Chemistry, Pharmacy Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

4 Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


Background: Carvacrol is the main phenolic compound of Satureja and thyme. Carvacrol has antibacterial, antifungal, anti-inflammatory, and anti-cancer properties.
Objectives: The aim of this study is determine the peptide-modified carvacrol’s antibacterial effects against Staphylococcus epidermidis and Pseudomonas aeruginosa.
Methods: The peptide-modified carvacrol’s antibacterial activity against Staphylococcus epidermidis and Pseudomonas aeruginosa was investigated by disk diffusion and MIC method.
Results: The effects of modified carvacrol by the disk diffusion method had growth inhibition diameters of 25mm and 20mm against Staphylococcus epidermidis and Pseudomonas aeruginosa, respectively. Also, MIC against Staphylococcus epidermidis and Pseudomonas aeruginosa was 1µg/ml and 0.51µg/ml, respectively.
Conclusion: The peptide-modified carvacrol has some antibacterial effects.


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