Antibacterial Activity of Modified Carvacrol against Staphylococcus epidermidis and Pseudomonas aeruginosa

Document Type : Original Article


1 Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

2 Department of Microbiology and Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Department of Medicinal Chemistry, Pharmacy Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

4 Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


Background: Carvacrol, a prominent phenolic compound found in Satureja and thyme, possesses a wide range of beneficial properties, including antibacterial, antifungal, anti-inflammatory, and anti-cancer activities.
Objectives: This study aimed to determine the antibacterial effects of peptide-modified carvacrol on Staphylococcus epidermidis and Pseudomonas aeruginosa.
Methods: Using disk diffusion and MIC methods, the antibacterial activity of peptide-modified carvacrol against Staphylococcus epidermidis and Pseudomonas aeruginosa was evaluated.
Results: The modified carvacrol demonstrated growth inhibition diameters of 25mm and 20mm against Staphylococcus epidermidis and Pseudomonas aeruginosa using the disk diffusion method. The minimum inhibitory concentration (MIC) against Staphylococcus epidermidis and Pseudomonas aeruginosa was 1 g/ml and 0.51 g/ml, respectively.
Conclusion: Peptide-modified carvacrol displays antibacterial effects.


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