Seroepidemiological prevalence of Helicobacter pylori in the south of Tehran, Iran

Document Type : Original Article


1 Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran

3 Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran

4 Amiran Oghyanoos Biotechnology Company, Tehran, Iran


Background: Helicobacter pylori (HP) is one of the most prevalent infections globally, particularly in developing countries like Iran. The assessment of the disease in Tehran, the capital of Iran, is essential due to its high population density, inadequate sanitation infrastructure, and economic challenges.
Objectives: This study aimed to evaluate the prevalence of anti-HP antibodies in patients referred to a clinical laboratory in Tehran, Iran, in 2019.
Methods: We evaluated anti-HP IgA and IgG antibodies using the ELISA method. Positive and negative results were analyzed. During this study, we examined a total of 593 patients who were referred to clinical laboratories due to symptoms of the disease. We collected serum samples from these patients and used them for diagnosis via an ELISA kit.
Results: Out of 593 patients, 451 tested positive for both antibodies. Additionally, 87% of patients tested positive for IgG, and 47.8% tested positive for IgA. The findings also demonstrated that among different age groups, patients above 70 years old had the highest percentage of positive results for IgG (90%), while the age group of 50–60 years old had the highest percentage of positive results for IgA (82%). There were no statistically significant differences between the genders.
Conclusion: It seems that the number of patients suffering from this disease is increasing in Tehran, and even younger age groups are now being affected. For a reliable diagnosis, the evaluation of both antibodies is recommended.


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